Bioplus Life Sciences

For over 70 years, BioPlus Life Sciences has served the pharmaceutical industry with high-quality products like glucosamine, sucralose, licorice, ketone supplement, services, and technology. With a better understanding of Nature with Science, they focus on manufacturing and marketing formulations of the highest quality.

• Contract manufacturing
• Pharmaceutical ingredients and formulations
• Nutritional ingredients and formulations
• Nanotechnology
• Personal Care

Their product range includes:

Sterlomax glucosamine

SterloMax Rub-in Hand Disinfectants & Sanitizers

SterloMax Is 0.2 Micron filtered, Fast-acting and Ready-to-use without water. Pure, hygienic, and effective during routine, high risk, and outbreak situations For hygienic and surgical hand disinfection, and to sanitize hard porous surfaces Available in 2 variants. Isopropyl alcohol-based and Ethanol-based Disinfectants & Sanitizers

Ingredients

• Propanol (Isopropyl alcohol): is the most common and widely used disinfectant within pharmaceutics, hospitals, cleanrooms, and electronics or medical device
• Ethanol: is the most commonly used disinfectant in hygienic and surgical hand rub preparations. Ethanol is active against vegetative bacteria, fungi, and lipid-containing viruses. Ethanol shows highest effectiveness at concentrations of approximately 70% (v/v) to 80% (v/v) in water: higher or lower concentrations may not be as germicidal
• Glycerol: Serves as an emollient to protect skin against dryness, dermatitis and helps preserve skin moisture
• Hydrogen peroxide: A widely used biocide for disinfection, sterilization, and antisepsis Demonstrates broad-spectrum efficacy against viruses, bacteria, yeasts, and bacterial spores

Ketoji glucosamine

Ketoji is the most ‘potent’ exogenous or oral source of therapeutic ketone supplement as Ketone ester (D-ßhydroxybutyrate ester). Designed for anyone considering to manage their weight, increase their cognition skills, or simply want to feel more energetic with a low carbohydrate diet. It is the only efficient fuel source that can completely sustain brain energy requirements even when blood glucose levels fall down. It helps to prolong the period of survival during caloric starvation, provides a potential new scientific approach to treat obesity, epilepsy, and other cognitive disorders.

• Dietetically / pharmaceutically acceptable carrier
• D-β-Hydroxybutyrate ester can be used as a supplement in food product, a beverage, a drink, a food supplement, a dietary supplement or a medicament marketed for high-performance athletes
• It can treat a condition which is caused by, exacerbated by or associated with elevated plasma levels of free fatty acids
• Promote alertness or improve cognitive function or prevent the effects of neurodegeneration, free radical toxicity, hypoxic conditions or hyperglycemia
• It can suppress appetite, support weight loss, maintains healthy weight or decrease the ratio of fat to lean muscle
• It can treat a muscle impairment (particularly cardiac or skeletal) and muscle fatigue

Lactopure glucosamine

Bacillus coagulans or Lactobacillus sporogenes is a gram-positive, facultative anaerobic, nonpathogenic, spore-forming, lactic acid-producing bacteria.

They secrete antibacterial substances like organic acids, hydrogen peroxide and bacteriocins to inhibit pathogenic bacteria.
Bacillus coagulans or Lactobacillus sporogenes: Good choice for the probiotics –

• Spore form: more resistant to high temperatures, moisture, acidity and negative environmental conditions during the manufacture of food than vegetative form
• Acid resistant spores: Does not get destroyed in gastric pH
• Heat resistant spores: provide an advantage for heat-treated probiotic foods
• Quick actions: Get released instantly in the intestine for action
• Broader action spectra: It inhibits both gram +ve & -ve pathogenic bacteria
• Storage and Better Shelf life: They also survives with limited nutrient to act effectively until the end of shelf life
• Qualified Presumption of Safety (QPS) status: GRAS approved 2 and EFSA reported its safety.

BioDHA glucosamine

DHA is the most abundant essential fatty acid in the brain and retina. It comprises 40% of the PUFAs in the brain and 60% of PUFAs in the retina. About 50% of the weight of the neuron’s plasma membrane is composed of DHA. The recent past has seen a surge in the promotion of DHA as a food additive. Its importance in healthcare has been ever increasing. BioPlus manufactures DHA by vegetative fermentation using microalgae:

• BioDHA algal Powder
• BioDHA algal oil

The major applications of BioDHA include – food ingredients in beverages, chocolates, ice creams, bakeries, yogurt, and infant food.

What is Algal DHA?

Algal DHA, a vegetarian, sustainable, and highly stable algal Omega-3 DHA produced from the microalgae Schizochytrium. Although fish oil is well known for having a high content of EPA and DHA, microalgae are the original source of marine omega-3. Algal DHA is the DHA in Algal oil that is derived directly from algae. It is fish-free, fermented, and extracted under a strictly controlled environment from start to finish. 100% vegetarian suitable for vegans, non-GMO, free from allergens. This oil contains DHA, which accounts for 97 percent of the omega-3 fats in the brain.

Why algal DHA?

Fish get their source of Omega 3 DHA from Marine Algae which can be a source of many contaminations and may be poisonous for consumption causing Burp and fishy after taste. Algal-oil DHA represents a safe and convenient source of non-fish-derived DHA which requires simple processing as it is a direct source from Algae. Algal DHA is relatively safe as the toxicological studies show no genotoxic or teratogenic data and have no effect on reproductive parameters. It is free from the contamination of Mercury, sea contaminants, and other heavy metals. Safety assessment of microalgae DHA comes under Noel Food Standards. Fish oil DHA is prone to oxidation but the algal DHA is stable as it contains natural antioxidants.

Why DHA?

DHA is the omega-3 fatty acid. The benefits of omega-3 fatty acids have been well-researched and established. DHA is an important brain nutrient, supports brain development and function, supports cognitive development, may support normal cognitive function throughout life, supports a healthy heart, a heart-healthy nutrient, retinal development, and function, supports visual development, supports the visual function. They’re known for being anti-inflammatory agents, and they help the body reduce blood clots. The inclusion of plentiful DHA in the diet improves learning ability, whereas deficiencies of DHA are associated with deficits in learning.

Glucosamine

Glucosamine is used for symptomatic relief of mild-to-moderate osteoarthritis (OA) of the knee. Glucosamine sulphate is a naturally occurring substance in the human body and is necessary for joint fluid and cartilage. Some of the characteristic features of Glucosamine are-

• Glucosamine slows down the cartilage damage in osteoarthritis patients
• Symptom-relieving effect with good safety profile in cases of OA
• Glucosamine is a normal component of glycosaminoglycans in the cartilage matrix and synovial fluid
• Glucosamine is utilized by the body to create glycosaminoglycans, an enzyme essential for cartilage repair
• Glucosamine plays important role in the synthesis of cell membrane lining, collagen, osteoid and bone matrix
• Glucosamine results in pain relief equivalent to some nonsteroidal anti‐inflammatory drugs (NSAIDs)

Vitamin ETPGS

Alpha Tocopheryl Polyethylene Glycol Succinate (TPGS) is widely used as a water-soluble vitamin E formulation. TPGS is synthesized from the lipid-soluble antioxidant, α-tocopherol (vitamin E) by grafting to a polyethylene glycol (PEG) oligomer through a succinate diester linker. Vitamin-E TPGS is amphiphile that is it has a dual nature. Vitamin-E TPGS is prepared from two different sources – Natural and synthetic vitamin E.

Applications

• Emulsifier
• Drug delivery system
• Dietary supplements
• Food and beverages
• Personal care
• Cosmetics
• Animal nutrition

Sucralose

BioPlus’s technology for manufacturing sucralose is thus the only alternative novel process that has achieved the specifications of International Standard equal to that of Tate & Lyle. Sucralose tastes exactly like sugar because it contains sweet-tasting sucralose. Sucralose is non-caloric, non-cariogenic and has no effect on blood glucose or insulin levels. It is therefore ideal for people with diabetes as well as for anyone who is trying to reduce their sugar intake to meet current healthy eating guidelines or to control their body weight. The safety of Sucralose has been thoroughly evaluated and is endorsed by many healthcare experts worldwide.

Sucralose: Key Advantages

• Tastes like sugar
• Zero calories
• Made from real sugar
• Exceptionally high – temperature stability
• Zero carbohydrates
• 600 times sweeter than sugar
• Can be used by all population groups
• Superior shelf life
• Outstanding processing versatility
• Already used in over 4000 products, including various products for children
• Ingredient compatibility

Liquorice

Licorice or Liquorice, is a unique tasting herb derived from the Glycyrrhiza glabra, the pea family. The edible and sweet root of licorice has been used in food and medicine for more than 4000 years. Licorice is available to consumers in form of liquid extract, dried solid root and root powder, licorice tea, candy, etc. One of the main ingredients in Licorice roots is glycyrrhizic acid, which is a natural sweetener/taste masker. Active chemical ingredient imparting the unique licorice taste is glycyrrhizic acid/glycyrrhizin, which is 50 times sweeter than sucrose

Key Features

• Natural
• Available in different forms
• Stable under most stable conditions
• Anti-viral, anti-bacterial, anti-inflammatory and anti-fungal properties
• Used in wide range of applications
• Generally recognized as safe (GRAS)
• Cosmetic Ingredient review (CIR) expert panel says as safe in required concentration

Applications

• Nutritional supplements
• Food and beverages
• Pharmaceuticals
• Cosmetics/personal care

Diosmectite

Diosmectite is a natural silicate of aluminum and magnesium, taking the form of layers of fine sheets. Each sheet has an octahedral layer of aluminum surrounded by two tetrahedral layers of silicon. Also, known as Smectites / Bentonite. Originate from the meteoric or hydrothermal degradation of feldspars, or other minerals. Found in massive rocky masses, suitable for industrial exploitation

Due to their properties, they exhibit high chemical inertness, high adsorption capacity, high internal surface area, and high cations exchange capacity. When used properly, there are very few problems associated with the use of diosmectite. This compound is considered safe for infants to take and has a low instance of side effects. It is relatively mild in its effects on the digestive system. Considered safe for young children and infants as well as adults.

Applications

It occurs naturally and is a common treatment for gastrointestinal illnesses. Diosmectite is a medication that is used to treat severe diarrhea quickly and effectively. Also used in the treatment of coeliac disease. It has also been known to relieve inflammation in the digestive system and can also help to rid the body of certain viruses or bacteria.

Adsorptive properties of clay help in healing skin ailments. In combination, this has been used in various topical applications. Hence extensively used in the cosmetic industry too.

Therapeutic Categories in brief

• Skin ailments
• Pharmaceutic aid
• Antacid
• Astringent agent
• Antidiarrheal agent: Intestinal adsorbent
• Protectant of gastrointestinal mucosa

DL-Lysine Acetylsalicylate

DL-Lysine Acetylsalicylate is a part of the non-steroidal anti-inflammatory drugs (NSAIDs) group, it may inhibit cancer cell line growth. It is water-soluble and, the compound is an analgesic, antipyretic and anti-inflammatory. Acetylsalicylates with basic amino acids such as DL-lysine are stabilized in the form of solid preparation.

Because of its limited solubility in water, aspirin has been prescribed as an oral drug. When orally administered, however, it is hydrolyzed by the strongly acidic gastric juice, forming salicylic acid which irritates the gastric mucosa. To avoid this, an attempt has been made to improve the method for administrating acetylsalicylic acid and succeeded in preparing a salt easily soluble in water by reacting acetylsalicylic acid and basic amino acid. Because of its instability in an aqueous medium, the acetylsalicylate of basic amino acid must be in the form of powder in order to ensure stability until the time when it is used.

Applications

• Non-steroidal anti-inflammatory drugs (NSAIDs) may inhibit cancer growth
• Water soluble, injectable aspirin derivative
• Analgesic; antipyretic; anti-inflammatory
• Acetylsalicylic acid (aspirin) has long been used as an analgesic, antipyretic and anti-rheumatic, more recently, it is widely used as a non-steroid anti-inflammatory in treating arthritis, neuralgia and myalgi.

Manufacturing Facility

Bioplus Park, Sipcot Industrial Area, Phase II,
Krishnagiri Main Road,
Hosur – 635 109,
Tamil Nadu, India

Phone: +91 43 4426 1976
Fax: +91 43 4426 0998

http://www.bioplus.in/index.html

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